Endocrine Abstracts

Androgens and increasing age are established risk factors associated with prostate cancer, Paradoxically, testosterone levels gradually decline with increasing age as the incidence of prostate cancer (PCa) rises in older men. Estrogens have been implicated in PCa as estrogen levels in older men remain relatively unchanged resulting in a decline in the ratio of androgens:estrogens with age. Thus the hormonal regulation of prostate cancer is not limited to a role for androgens a...

A breakdown in stromal-epithelial interactions mediated by androgens is emerging as a key factor in prostate cancer (PCa) aetiology and progression. Currently however, we have limited knowledge of the mechanics of androgen and androgen receptor (AR) action in prostate stroma, or how dysfunction in that compartment contributes to the disease process.In this study, immunohistochemical analysis of 64 PCa samples revealed an inverse relationship between stro...